課程資訊
課程名稱
生物系統模擬及計算二
SIMULATION AND COMPUTATION FOR BIOSYSTEMS(II) 
開課學期
99-1 
授課對象
生物資源暨農學院  生物環境系統工程學研究所  
授課教師
廖中明 
課號
BSE8009 
課程識別碼
622 D0380 
班次
 
學分
全/半年
半年 
必/選修
選修 
上課時間
星期四2,3,4(9:10~12:10) 
上課地點
農工金城 
備註
總人數上限:15人 
 
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課程概述

Instructor: Dr. Chung-Min Liao, Department of Bioenvironmental Systems Engineering, National Taiwan University

Topics:
● Basics and Techniques for Modeling Deterministic Compartmental
Systems
● Basics and Techniques for Modeling Stochastic Compartmental
Systems
● Identifiability
● Estimation and Estimability
● Design of Experiments
● Applications

 

課程目標
The objectives are to apply the mathematical modeling and computation tchniques to investigate the prombles of environmental systems.  
課程要求
Grading Policy:
1.Home Work: 30%
2.Term Paper: 30%
3.Oral presentation: 40%
 
預期每週課後學習時數
 
Office Hours
 
指定閱讀
1.Jacquez, JA. 1996. (3rd ED.) Compartmental Analysis in Biology
and Medicine. BioMedware, Ann Arbor, MI.
2.Jacquez, JA. 1999. Modeling with Compartments. BioMedware, Amm
Arbpr, MI.
3.Ekins, S. 2007. Computational Toxicology. John Wiley & Sons, New Jersey.
4.Lecture Notes. 
參考書目
● Journals.
1.Environmental Toxicology and Chemistry
2.Biosystems
3.Ecosystems
4.Toxicology and Applied Pharmacology
5.Ecological Modelling
6.Applied Mathematical Modelling
7.Environmental Science and Technology
8.Mathematical Biosciences 
評量方式
(僅供參考)
   
課程進度
週次
日期
單元主題
第1週
9/16  Compartmental Systems  
第2週
9/23  Linear Compartmental Systems with Constant Coefficients 
第3週
9/30  Linear Compartmental Systems with Periodic Coefficients 
第4週
10/07  System with Time Lag 
第5週
10/14  Modeling and Modeling Systems 
第6週
10/21  Compartmental Systems with Linear Rate Law 
第7週
10/28  Nonlinear Law in Basically Deterministic Compartmental Systems 
第8週
11/04  Model Applications 
第9週
11/11  Oral Presention (I) 
第10週
11/18  An Introduction to Toxicology and Its Methodologies 
第11週
11/25  Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling 
第12週
12/02  Systems Toxicology 
第13週
12/09  Computational Approaches for Assessment of Toxicity 
第14週
12/16  Application of Interpretable Models to ADME/TOX Problems 
第15週
12/23  Application in Aquatic Toxicology 
第16週
12/30  Environmental and Ecological Toxicology: Computational Risk Assessment 
第17週
1/06  Oral presention (II)